UCR

Center for Plant Cell Biology



Members


Hailing JinHailing Jin

Professor

Mailing Address:

Plant Pathology and Microbiology
Genomics Building /3234B
University of California
Riverside, CA 92521

Phone: (951) 827-7995
Fax: (951) 827-4294
Email: hailingj@ucr.edu

Degree(s):

PhD 1996 Shanghai Institute of Plant Physiology and Ecology

College/Division Affiliation:

College of Natural and Agricultural Sciences

Center/Inst Affiliation(s):

Center for Plant Cell Biology

Areas Of Expertise:

Small RNA-mediated Gene Regulation; Plant Immunity

Awards / Honors:

2010-15  NIH R01 Award
2007-12  NSF Career Award
2008-09  UCR-LANL Collaborative Award
2006-09  UC Discovery Award
2006-10  Awards from California Citrus Research Board
2007-08  Interdisciplinary Research Award, Institute for Integrative Genome Biology
2004, 2006  UC Regents' Faculty Development Award

Research Summary:

The research goal in my laboratory is to understand the molecular mechanism of plant immune responses against bacterial and fungal pathogens, and ultimately develop effective means of disease control. The major focus of our lab is to study small RNA-mediated gene regulation and epigenetic control in plant immune responses.

My laboratory studies signal transduction and gene regulation in plant disease resistance and defense responses. Small RNAs, including microRNAs (miRNAs) and small interfering RNAs (siRNAs), have emerged as important regulators of eukaryotic gene expression by guiding mRNA cleavage, translational inhibition or chromatin modification. Small RNA-induced gene silencing is a conserved regulatory process that has evolved as an antiviral defense mechanism in plants and animals. However, the roles of small RNAs in antibacterial or antifungal defense are less explored. The discovery of a bacteria-induced siRNA in my lab provided the first example of the regulatory role of siRNAs in plant immunity. Functional analysis of the siRNA target has led to the identification of a negative regulator of the resistance gene RPS2 signaling pathway. This study suggests a broader role of small RNAs in host-defense mechanisms.

We are utilizing genomics, genetics and biochemical approaches to identify and characterize pathogen-regulated small RNAs and their targets during the host defense responses. We are also investigating host epigenetic changes in response to pathogen attacks. We aim to identify novel signaling genes within disease resistance network and to elucidate the crosstalk between multiple signal transduction pathways. We have built up multiple systems, including both basic molecular studies and applied research. The basic model systems of interaction between bacterial and fungal pathogens and Arabidopsis host aim to address the basic molecular mechanisms in plant immunity. The applied research systems of the Huanglongbin disease in citrus (citrus greening) and the grey mold disease in tomato were built up based on the knowledge we gained from the Arabidopsis studies and aim to address more economically important problems in the agriculture. These projects have the potential to reveal new regulatory mechanisms underlying plant immunity, and will ultimately contribute to crop protection in the field.

Related Press Releases:

Selected Publications:

Publications from PubMed

Lab Personnel:

Padmanabhan, Chellappan
Assistant Specialist —
Zhang, Xiaoming
Postdoctoral Researcher —
Weiberg, Arne
Postdoctoral Researcher —
Zhao, Hongwei
Postdoctoral Researcher —
Gao, Shang
Graduate Student Researcher —
Wang, Ming
Graduate Student Researcher —
Zhu, Pei
Graduate Student Researcher —
Peralta Karl; Wong, Timothy; Wu, Eric
Undergraduate Student Researchers —
Jin Lab 2008
 Jin Lab 2008
Jin Lab 2010
Jin Lab 2010

 

 


More Information

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Career OpportunitiesUCR Libraries
Campus StatusDirections to UCR

Center Information

Center for Plant Cell Biology
Botany & Plant Sciences Department
2150 Batchelor Hall

Tel: (951) 827-7177
Fax: (951) 827-5155
E-mail: genomics@ucr.edu

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